Extracto de germen de trigo rico en espermidina / Espermidina 124-20-9

El extracto de germen de trigo rico en espermidina es un nuevo tipo de alimento reconocido por la Comisión Europea. La espermidina puede apoyar la autofagia, un proceso de autolimpieza que ocurre en las células del cuerpo, que está relacionado con un sistema inmunológico saludable y también puede retrasar el envejecimiento. Este nuevo ingrediente también aporta otros nutrientes, como el ácido fólico, que interviene en la defensa inmunitaria, y la vitamina E, que protege las células. Es un clásico ingrediente antienvejecimiento. También contiene un alto valor nutricional de proteína vegetal y grasa. Según las características de salud de la materia prima, se puede aplicar al desarrollo de productos en los segmentos de mercado de salud general y envejecimiento saludable.

Función de la espermidina

① Spermidine is named after it was first extracted from semen.It is a polyamine (made by the polymerization of two or more amino groups);In the human body, there are two main types of polyamines, spermidine and spermine. Polyamines play an important role in cell growth and tissue differentiation.They can bind and stabilize DNA and RNA, regulate the function of enzymes in cells, and also play an antioxidant role.

② Regardless of whether it is an animal or a human, the concentration of spermidine in the body will decrease with age.One of the main reasons is that the activity of polyamine producing enzymes in the body will decrease.In most elderly people, the level of spermidine is low. However, among healthy 90-year-olds and centenarians, spermidine in the tissues still maintains the level of middle-aged people. Studies have also found that in Asian countries, the higher the intake of spermidine, the higher the local life expectancy.

③ Spermidine may play a certain role in the treatment of cancer, cardiovascular diseases, metabolic diseases and neurodegenerative diseases.In mice with cancer, spermidine supplementation can enhance their own immune surveillance, thereby reducing tumor growth. For cardiovascular diseases, epidemiological studies have shown that the more people who consume spermidine, the lower the morbidity and mortality of cardiovascular diseases. A high-sugar and high-fat diet can induce the occurrence of metabolic diseases; while supplementing spermidine on mice on a high-sugar and high-fat diet can prevent obesity and improve glucose tolerance. In the neuropathy of multiple sclerosis, spermidine can reduce the demyelination of neurons caused by autoimmunity.

④ The mechanism by which spermidine works mainly depends on activating the body's autophagy . You should remember that the so-called autophagy is the self-cleaning process of cells—cleaning out unnecessary garbage and reducing the occurrence of cell apoptosis and cancer. Direct injection of spermidine will activate autophagy in the heart, liver and muscles within 4-24 hours. At the same time, the body's metabolism has also entered a state similar to fasting. Oral spermidine supplementation usually triggers autophagy in heart tissue within 2-4 weeks and reverses the problem of insufficient autophagy caused by aging. Moreover, in addition to promoting autophagy, spermidine can also trigger mitochondrial autophagy, thereby promoting the health of mitochondria.

⑤ Spermidine can play a broad-spectrum anti-inflammatory effect, such as inhibiting TNF- α and NFkB, and can relieve fatal sepsis.Part of this effect comes from autophagy, and the other part lies in its direct regulation of immune cells.

⑥ In addition to activating autophagy and anti-inflammatory , spermidine can also open up many important anti-aging channels.On the one hand, it can inhibit mTOR, on the other hand, it can activate AMPK, thus having a comprehensive "anti-aging" effect.

⑦ Curiosamente, la espermidina puede promover el crecimiento del cabello. En experimentos in vitro, la espermidina puede aumentar la expresión de queratina K15 y K19 en las células madre epiteliales del cabello. En 6 días, con una dosis de 0,5 uM, puede aumentar el tallo del cabello hasta en un 20%.